“Pσlice say the cases aren’t believed to be linked — but many are focused on one striking detail” Four girls have vɑnished over the spɑce of just two weeks, prompting an urgent appeal to the public as investigators work to piece together what happened.

Police have called on the public for help locating four young girls who have gone missing across Western Sydney in a matter of weeks.

Two of the girls, Rose and Connie Trindall, both vanished from Liddle St in St Marys on Wednesday.

Police told 7NEWS.com.au the girls are known to each other.

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Connie, 11, is described as being of Aboriginal or Torres Strait Islander appearance, about 155cm tall with a think build and long dark brown hair.

Rose, 13, is also described as being of Aboriginal or Torres Strait Islander appearance, about 145cm tall with an average build and long dark brown hair.

Both girls are known to frequent St Marys and Redfern.

It comes after the disappearance of 17-year-old Jadea Gillon on May 25 from Verills Gr in Oakhurst, about 6km east of the Trindalls’ last known location.

Gillon is known to frequent the Plumpton area and is described as Caucasian, about 155cm tall, with a slim build and shoulder-length light brown hair.

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She vanished just three days after another 17-year-old girl, Shay-Lee Hosa.

Hosa was last seen on George St in Parramatta and is described as Caucasion, about 165cm tall, with a slim build and shoulder-length blonde fair. She is known to frequent Blacktown and Warwick Farm.

Police hold concerns for each girl and told 7NEWS.com.au there was no indication the cases of Hosa and Gillion were linked to either Trindall girl.

Anyone with information regarding the missing persons cases have been urged to contact Crime Stoppers.